1AD5

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

Summary for 1AD5

Entry DOI	10.2210/pdb1ad5/pdb
Descriptor	HAEMATOPOETIC CELL KINASE HCK, CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
Functional Keywords	tyrosine-protein kinase, transferase, signal transduction, sh2, sh3, phosphorylation
Biological source	Homo sapiens (human)
Cellular location	Isoform p59-HCK: Membrane; Lipid-anchor. Isoform p60-HCK: Membrane; Lipid-anchor: P08631
Total number of polymer chains	2
Total formula weight	101781.40
Authors	Sicheri, F.,Moarefi, I.,Kuriyan, J. (deposition date: 1997-02-20, release date: 1997-05-15, Last modification date: 2024-10-23)
Primary citation	Sicheri, F.,Moarefi, I.,Kuriyan, J. Crystal structure of the Src family tyrosine kinase Hck. Nature, 385:602-609, 1997 Cited by PubMed Abstract: The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases. PubMed: 9024658 DOI: 10.1038/385602a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation