1AD5

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

1AD5 の概要

• エントリーDOI: 10.2210/pdb1ad5/pdb
• 分子名称: HAEMATOPOETIC CELL KINASE HCK, CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
• 機能のキーワード: tyrosine-protein kinase, transferase, signal transduction, sh2, sh3, phosphorylation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform p59-HCK: Membrane; Lipid-anchor. Isoform p60-HCK: Membrane; Lipid-anchor: P08631
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 101781.40

構造登録者

Sicheri, F.,Moarefi, I.,Kuriyan, J. (登録日: 1997-02-20, 公開日: 1997-05-15, 最終更新日: 2024-10-23)

主引用文献

Sicheri, F.,Moarefi, I.,Kuriyan, J.
Crystal structure of the Src family tyrosine kinase Hck.
Nature, 385:602-609, 1997

PubMed Abstract: The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

PubMed: 9024658
DOI: 10.1038/385602a0

実験手法

X-RAY DIFFRACTION (2.6 Å)