1AA7

INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0

1AA7 の概要

• エントリーDOI: 10.2210/pdb1aa7/pdb
• 分子名称: INFLUENZA VIRUS MATRIX PROTEIN (2 entities in total)
• 機能のキーワード: viral assembly, virion budding, transcription repressor, matrix protein
• 由来する生物種: unidentified influenza virus
• 細胞内の位置: Virion membrane ; Peripheral membrane protein ; Cytoplasmic side : P03485
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34804.40

構造登録者

Sha, B.,Luo, M. (登録日: 1997-01-24, 公開日: 1998-01-28, 最終更新日: 2024-02-07)

主引用文献

Sha, B.,Luo, M.
Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1.
Nat.Struct.Biol., 4:239-244, 1997

PubMed Abstract: Matrix protein (M1) of influenza virus is a bifunctional protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously. The X-ray crystal structure of the N-terminal portion of type A influenza virus M1-amino acid residues 2-158-has been determined at 2.08 A resolution at pH 4.0. The protein forms a dimer. A highly positively charged region on the dimer surface is suitably positioned to bind RNA while the hydrophobic surface opposite the RNA binding region may be involved in interactions with the membrane. The membrane-binding hydrophobic surface could be buried or exposed after a conformational change.

PubMed: 9164466
DOI: 10.1038/nsb0397-239

実験手法

X-RAY DIFFRACTION (2.08 Å)