1A9M

G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E

Summary for 1A9M

DescriptorHIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total)
Functional Keywordsaspartyl protease, drug resistant, mutation
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total molecular weight22366.47
Authors
Hong, L.,Zhang, X.-J.,Foundling, S.,Hartsuck, J.A.,Tang, J. (deposition date: 1998-04-08, release date: 1998-06-17, Last modification date: 2011-07-13)
Primary citation
Hong, L.,Zhang, X.J.,Foundling, S.,Hartsuck, J.A.,Tang, J.
Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.
FEBS Lett., 420:11-16, 1997
PubMed: 9450540 (PDB entries with the same primary citation)
DOI: 10.1016/S0014-5793(97)01477-4
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers11013.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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