1A9M

G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E

1A9M の概要

• エントリーDOI: 10.2210/pdb1a9m/pdb
• 分子名称: HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total)
• 機能のキーワード: aspartyl protease, drug resistant, mutation
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22366.47

構造登録者

Hong, L.,Zhang, X.-J.,Foundling, S.,Hartsuck, J.A.,Tang, J. (登録日: 1998-04-08, 公開日: 1998-06-17, 最終更新日: 2024-05-22)

• 主引用文献: Hong, L.,Zhang, X.J.,Foundling, S.,Hartsuck, J.A.,Tang, J.; Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.; FEBS Lett., 420:11-16, 1997; PubMed: 9450540; DOI: 10.1016/S0014-5793(97)01477-4

実験手法

X-RAY DIFFRACTION (2.3 Å)