1A8M

TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT

Summary for 1A8M

• Entry DOI: 10.2210/pdb1a8m/pdb
• Descriptor: TUMOR NECROSIS FACTOR ALPHA (2 entities in total)
• Functional Keywords: lymphokine, cytokine, cytotoxin
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375
• Total number of polymer chains: 3
• Total formula weight: 51985.65

Authors

Reed, C.,Fu, Z.-Q.,Wu, J.,Xue, Y.-N.,Harrison, R.W.,Chen, M.-J.,Weber, I.T. (deposition date: 1998-03-27, release date: 1998-06-17, Last modification date: 2023-08-02)

• Primary citation: Reed, C.,Fu, Z.Q.,Wu, J.,Xue, Y.N.,Harrison, R.W.,Chen, M.J.,Weber, I.T.; Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.; Protein Eng., 10:1101-1107, 1997; PubMed: 9488135; DOI: 10.1093/protein/10.10.1101

Experimental method

X-RAY DIFFRACTION (2.3 Å)