1A8I

SPIROHYDANTOIN INHIBITOR OF GLYCOGEN PHOSPHORYLASE

Summary for 1A8I

• Entry DOI: 10.2210/pdb1a8i/pdb
• Descriptor: GLYCOGEN PHOSPHORYLASE B, BETA-D-GLUCOPYRANOSE SPIROHYDANTOIN (3 entities in total)
• Functional Keywords: glycogen phosphorylase, glucopyranose spirohydantoin, water structure, inhibitor binding, anti-hyperglycemic agent
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 97767.51

Authors

Gregoriou, M.,Noble, M.E.M.,Watson, K.A.,Garman, E.F.,Krulle, T.M.,De La Fuente, C.,Fleet, G.W.J.,Oikonomakos, N.G.,Johnson, L.N. (deposition date: 1998-03-25, release date: 1998-07-01, Last modification date: 2023-08-02)

• Primary citation: Gregoriou, M.,Noble, M.E.,Watson, K.A.,Garman, E.F.,Krulle, T.M.,de la Fuente, C.,Fleet, G.W.,Oikonomakos, N.G.,Johnson, L.N.; The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.; Protein Sci., 7:915-927, 1998; PubMed: 9568898

Experimental method

X-RAY DIFFRACTION (1.78 Å)