1A87

COLICIN N

1A87 の概要

• エントリーDOI: 10.2210/pdb1a87/pdb
• 分子名称: COLICIN N (2 entities in total)
• 機能のキーワード: bacteriocin, toxin, pore-forming activity
• 由来する生物種: Escherichia coli K12
• 細胞内の位置: Cell membrane; Multi-pass membrane protein (Potential): P08083
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35146.27

構造登録者

Vetter, I.R.,Parker, M.W.,Tucker, A.D.,Lakey, J.H.,Pattus, F.,Tsernoglou, D. (登録日: 1998-04-03, 公開日: 1999-04-06, 最終更新日: 2024-02-07)

主引用文献

Vetter, I.R.,Parker, M.W.,Tucker, A.D.,Lakey, J.H.,Pattus, F.,Tsernoglou, D.
Crystal structure of a colicin N fragment suggests a model for toxicity.
Structure, 6:863-874, 1998

PubMed Abstract: Pore-forming colicins are water-soluble bacteriocins capable of binding to and translocating through the Escherichia coli cell envelope. They then undergo a transition to a transmembrane ion channel in the cytoplasmic membrane leading to bacterial death. Colicin N is the smallest pore-forming colicin known to date (40 kDa instead of the more usual 60 kDa) and the crystal structure of its membrane receptor, the porin OmpF, is already known. Structural knowledge of colicin N is therefore important for a molecular understanding of colicin toxicity and is relevant to toxic mechanisms in general.

PubMed: 9687368
DOI: 10.1016/S0969-2126(98)00088-4

実験手法

X-RAY DIFFRACTION (3.1 Å)