1A84

NMR SOLUTION STRUCTURE OF A DNA DODECAMER DUPLEX CONTAINING A CIS-DIAMMINEPLATINUM(II) D(GPG) INTRASTRAND CROSS-LINK, THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN, 1 STRUCTURE

1A84 の概要

• エントリーDOI: 10.2210/pdb1a84/pdb
• 分子名称: DNA D(CCTCTG*G*TCTCC), DNA D(GGAGACCAGAGG), Cisplatin (3 entities in total)
• 機能のキーワード: deoxyribonucleic acid, cisplatin, dna, duplex, dodecamer, hmg-domain interaction
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7626.83

構造登録者

Gelasco, A.,Lippard, S.J. (登録日: 1998-04-02, 公開日: 1998-11-25, 最終更新日: 2024-04-10)

• 主引用文献: Gelasco, A.,Lippard, S.J.; NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin.; Biochemistry, 37:9230-9239, 1998; PubMed: 9649303; DOI: 10.1021/bi973176v

実験手法

SOLUTION NMR