1A7S

ATOMIC RESOLUTION STRUCTURE OF HBP

1A7S の概要

• エントリーDOI: 10.2210/pdb1a7s/pdb
• 分子名称: HEPARIN BINDING PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: serine protease homolog, endotoxin binding, heparin
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25674.56

構造登録者

Karlsen, S.,Iversen, L.F.,Larsen, I.K.,Flodgaard, H.J.,Kastrup, J.S. (登録日: 1998-03-17, 公開日: 1999-03-23, 最終更新日: 2024-11-06)

主引用文献

Karlsen, S.,Iversen, L.F.,Larsen, I.K.,Flodgaard, H.J.,Kastrup, J.S.
Atomic resolution structure of human HBP/CAP37/azurocidin.
Acta Crystallogr.,Sect.D, 54:598-609, 1998

PubMed Abstract: Crystals of human heparin binding protein (HBP) diffract to 1.1 A when flash-frozen at 120 K. The atomic resolution structure has been refined anisotropically using SHELXL96. The final model of HBP consists of 221 amino-acid residues of 225 possible, three glycosylation units, one chloride ion, 15 precipitant ethanol molecules and 323 water molecules. The structure is refined to a final crystallographic R factor of 15.9% and Rfree(5%) of 18.9% using all data. A putative protein kinase C activation site has been identified, involving residues 113-120. The structure is compared to the previously determined 2.3 A resolution structure of HBP.

PubMed: 9761855
DOI: 10.1107/S0907444997016193

実験手法

X-RAY DIFFRACTION (1.12 Å)