1A72

AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD

1A72 の概要

• エントリーDOI: 10.2210/pdb1a72/pdb
• 分子名称: HORSE LIVER ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase (nad(a)-choh(d)), active site mutant, liver alcohol dehydrogenase, isosteric nad inhibitors, oxidoreductase
• 由来する生物種: Equus caballus (horse)
• 細胞内の位置: Cytoplasm: P00327
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40658.50

構造登録者

Colby, T.D.,Bahnson, B.J.,Chin, J.K.,Klinman, J.P.,Goldstein, B.M. (登録日: 1998-03-19, 公開日: 1998-06-17, 最終更新日: 2023-08-02)

• 主引用文献: Colby, T.D.,Bahnson, B.J.,Chin, J.K.,Klinman, J.P.,Goldstein, B.M.; Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.; Biochemistry, 37:9295-9304, 1998; PubMed: 9649310; DOI: 10.1021/bi973184b

実験手法

X-RAY DIFFRACTION (2.6 Å)