1A6S

M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES

1A6S の概要

• エントリーDOI: 10.2210/pdb1a6s/pdb
• 分子名称: GAG POLYPROTEIN (1 entity in total)
• 機能のキーワード: core protein, virus structure, membrane binding, viral protein
• 由来する生物種: Rous sarcoma virus - Prague C
• 細胞内の位置: Matrix protein p19: Virion (Potential). Capsid protein p27: Virion (Potential). Nucleocapsid protein p12: Virion (Potential): P03322
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9179.75

構造登録者

Mcdonnell, J.M.,Fushman, D.,Cahill, S.M.,Zhou, W.,Wolven, A.,Wilson, C.B.,Nelle, T.D.,Resh, M.D.,Wills, J.,Cowburn, D. (登録日: 1998-03-02, 公開日: 1998-10-14, 最終更新日: 2024-05-22)

主引用文献

McDonnell, J.M.,Fushman, D.,Cahill, S.M.,Zhou, W.,Wolven, A.,Wilson, C.B.,Nelle, T.D.,Resh, M.D.,Wills, J.,Cowburn, D.
Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus
J.Mol.Biol., 279:921-928, 1998

PubMed Abstract: A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization.

PubMed: 9642071
DOI: 10.1006/jmbi.1998.1788

実験手法

SOLUTION NMR