1A6C

STRUCTURE OF TOBACCO RINGSPOT VIRUS

1A6C の概要

• エントリーDOI: 10.2210/pdb1a6c/pdb
• 分子名称: TOBACCO RINGSPOT VIRUS CAPSID PROTEIN (1 entity in total)
• 機能のキーワード: trsv, nepovirus, virus structure, virus evolution, picornavirus superfamily, virus capsid protein, icosahedral virus, virus
• 由来する生物種: Tobacco ringspot virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56993.65

構造登録者

Johnson, J.E.,Chandrasekar, V. (登録日: 1998-02-23, 公開日: 1998-07-15, 最終更新日: 2024-04-03)

主引用文献

Chandrasekar, V.,Johnson, J.E.
The structure of tobacco ringspot virus: a link in the evolution of icosahedral capsids in the picornavirus superfamily.
Structure, 6:157-171, 1998

PubMed Abstract: Tobacco ringspot virus (TRSV) is a member of the nepovirus genus of icosahedral RNA plant viruses that cause disease in fruit crops. Nepoviruses, comoviruses and picornaviruses are classified in the picornavirus superfamily. Crystal structures of comoviruses and picornaviruses and the molecular mass of the TRSV subunit (sufficient to accommodate three beta-barrel domains) suggested that nepoviruses may represent a link in the evolution of the picornavirus capsids from a T = 3 icosahedral virus. This evolutionary process is thought to involve triplication of the capsid protein gene, to encode a three-domain polyprotein, followed by development of cleavage sites in the interdomain linking regions. Structural studies on TRSV were initiated to determine if the TRSV subunit corresponds to the proposed uncleaved three-domain polyprotein.

PubMed: 9519407
DOI: 10.1016/S0969-2126(98)00018-5

実験手法

X-RAY DIFFRACTION (3.5 Å)