1A5W

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3

1A5W の概要

• エントリーDOI: 10.2210/pdb1a5w/pdb
• 分子名称: INTEGRASE, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID (3 entities in total)
• 機能のキーワード: hydrolase, endonuclease, hiv-1 integrase inhibitor
• 由来する生物種: Rous sarcoma virus (strain Schmidt-Ruppin)
• 細胞内の位置: Matrix protein p19: Virion (Potential). Capsid protein p27: Virion (Potential). Nucleocapsid protein p12: Virion (Potential): P03354
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17760.27

構造登録者

Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A. (登録日: 1998-02-18, 公開日: 1998-05-27, 最終更新日: 2023-08-02)

• 主引用文献: Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A.,Zhao, H.,Burke Jr., T.R.,Neamati, N.,Pommier, Y.,Merkel, G.,Skalka, A.M.; Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.; Proc.Natl.Acad.Sci.USA, 95:4831-4836, 1998; PubMed: 9560188; DOI: 10.1073/pnas.95.9.4831

実験手法

X-RAY DIFFRACTION (2 Å)