1A4W
CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE
Summary for 1A4W
| Entry DOI | 10.2210/pdb1a4w/pdb |
| Related PRD ID | PRD_000622 |
| Descriptor | ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total) |
| Functional Keywords | serine protease-inhibitor, blood coagulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted, extracellular space: P00734 P09945 Secreted: P00734 |
| Total number of polymer chains | 3 |
| Total formula weight | 36072.09 |
| Authors | Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A. (deposition date: 1998-02-06, release date: 1998-04-29, Last modification date: 2023-08-02) |
| Primary citation | Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A. Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site. Biophys.J., 71:2830-2839, 1996 Cited by PubMed: 8913620PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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