1A4W

CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE

1A4W の概要

• エントリーDOI: 10.2210/pdb1a4w/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000622
• 分子名称: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total)
• 機能のキーワード: serine protease-inhibitor, blood coagulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P09945; Secreted: P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36072.09

構造登録者

Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A. (登録日: 1998-02-06, 公開日: 1998-04-29, 最終更新日: 2023-08-02)

• 主引用文献: Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A.; Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.; Biophys.J., 71:2830-2839, 1996; PubMed: 8913620

実験手法

X-RAY DIFFRACTION (1.8 Å)