1A48
SAICAR SYNTHASE
Summary for 1A48
| Entry DOI | 10.2210/pdb1a48/pdb |
| Descriptor | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, SULFATE ION (3 entities in total) |
| Functional Keywords | atp binding protein, phosphoribosylaminoimidazolesuccinocarboxamide (saicar) synthase, purine biosynthesis |
| Biological source | Saccharomyces cerevisiae (baker's yeast) |
| Total number of polymer chains | 1 |
| Total formula weight | 34737.36 |
| Authors | Levdikov, V.M.,Melik-Adamyan, W.R.,Lamzin, V.S.,Wilson, K.S. (deposition date: 1998-02-12, release date: 1999-03-30, Last modification date: 2024-11-20) |
| Primary citation | Levdikov, V.M.,Barynin, V.V.,Grebenko, A.I.,Melik-Adamyan, W.R.,Lamzin, V.S.,Wilson, K.S. The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis. Structure, 6:363-376, 1998 Cited by PubMed Abstract: The biosynthesis of key metabolic components is of major interest to biologists. Studies of de novo purine synthesis are aimed at obtaining a deeper understanding of this central pathway and the development of effective chemotherapeutic agents. Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase catalyses the seventh step out of ten in the biosynthesis of purine nucleotides. To date, only one structure of an enzyme involved in purine biosynthesis has been reported: adenylosuccinate synthetase, which catalyses the first committed step in the synthesis of AMP from IMP. PubMed: 9551557DOI: 10.1016/S0969-2126(98)00038-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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