1A48

SAICAR SYNTHASE

1A48 の概要

• エントリーDOI: 10.2210/pdb1a48/pdb
• 分子名称: PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, SULFATE ION (3 entities in total)
• 機能のキーワード: atp binding protein, phosphoribosylaminoimidazolesuccinocarboxamide (saicar) synthase, purine biosynthesis
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34737.36

構造登録者

Levdikov, V.M.,Melik-Adamyan, W.R.,Lamzin, V.S.,Wilson, K.S. (登録日: 1998-02-12, 公開日: 1999-03-30, 最終更新日: 2024-11-20)

主引用文献

Levdikov, V.M.,Barynin, V.V.,Grebenko, A.I.,Melik-Adamyan, W.R.,Lamzin, V.S.,Wilson, K.S.
The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis.
Structure, 6:363-376, 1998

PubMed Abstract: The biosynthesis of key metabolic components is of major interest to biologists. Studies of de novo purine synthesis are aimed at obtaining a deeper understanding of this central pathway and the development of effective chemotherapeutic agents. Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase catalyses the seventh step out of ten in the biosynthesis of purine nucleotides. To date, only one structure of an enzyme involved in purine biosynthesis has been reported: adenylosuccinate synthetase, which catalyses the first committed step in the synthesis of AMP from IMP.

PubMed: 9551557
DOI: 10.1016/S0969-2126(98)00038-0

実験手法

X-RAY DIFFRACTION (1.9 Å)