1A25

C2 DOMAIN FROM PROTEIN KINASE C (BETA)

1A25 の概要

• エントリーDOI: 10.2210/pdb1a25/pdb
• 分子名称: PROTEIN KINASE C (BETA), CALCIUM ION, O-PHOSPHOETHANOLAMINE, ... (4 entities in total)
• 機能のキーワード: calcium++/phospholipid binding protein, calcium-binding protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cytoplasm: P68403
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34175.78

構造登録者

Sutton, R.B.,Sprang, S.R. (登録日: 1998-01-16, 公開日: 1998-05-06, 最終更新日: 2024-05-22)

主引用文献

Sutton, R.B.,Sprang, S.R.
Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Structure, 6:1395-1405, 1998

PubMed Abstract: Conventional isoforms (alpha, beta and gamma) of protein kinase C (PKC) are synergistically activated by phosphatidylserine and Ca2+; both bind to C2 domains located within the PKC amino-terminal regulatory regions. C2 domains contain a bipartite or tripartite Ca2+-binding site formed by opposing loops at one end of the protein. Neither the structural basis for cooperativity between phosphatidylserine and Ca2+, nor the binding site for phosphatidylserine are known.

PubMed: 9817842
DOI: 10.1016/S0969-2126(98)00139-7

実験手法

X-RAY DIFFRACTION (2.7 Å)