1A1V

HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA

1A1V の概要

分子名称DNA (5'-D(*UP*UP*UP*UP*UP*UP*UP*U)-3'), PROTEIN (NS3 PROTEIN), SULFATE ION, ... (4 entities in total)
機能のキーワードhepatitis c virus, rna helicase, nonstructural proteins, single-stranded dna, hydrolase-dna complex, hydrolase/dna
由来する生物種Hepatitis C virus (isolate H)
詳細
細胞内の位置Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein  P27958
ポリマー鎖数2
分子量合計53734.73
構造登録者
Kim, J.L.,Morgenstern, K.A.,Griffith, J.P.,Dwyer, M.D.,Thomson, J.A.,Murcko, M.A.,Lin, C.,Caron, P.R. (登録日: 1997-12-17, 公開日: 1999-01-13, 最終更新日: 2011-07-13)
主引用文献
Kim, J.L.,Morgenstern, K.A.,Griffith, J.P.,Dwyer, M.D.,Thomson, J.A.,Murcko, M.A.,Lin, C.,Caron, P.R.
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.
Structure, 6:89-100, 1998
PubMed: 9493270 (主引用文献が同じPDBエントリー)
DOI: 10.1016/S0969-2126(98)00010-0
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers901.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード