1A1K

RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GACC SITE)

Summary for 1A1K

• Entry DOI: 10.2210/pdb1a1k/pdb
• Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*TP*CP*CP*CP*AP*CP*GP*C)-3'), RADR ZIF268 VARIANT, ... (5 entities in total)
• Functional Keywords: complex (zinc finger-dna), zinc finger, dna-binding protein, transcription-dna complex, transcription/dna
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 3
• Total formula weight: 17701.07

Authors

Elrod-Erickson, M.,Benson, T.E.,Pabo, C.O. (deposition date: 1997-12-10, release date: 1998-06-10, Last modification date: 2023-08-02)

Primary citation

Elrod-Erickson, M.,Benson, T.E.,Pabo, C.O.
High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6:451-464, 1998

PubMed Abstract: Zinc fingers of the Cys2-His2 class comprise one of the largest families of eukaryotic DNA-binding motifs and recognize a diverse set of DNA sequences. These proteins have a relatively simple modular structure and key base contacts are typically made by a few residues from each finger. These features make the zinc finger motif an attractive system for designing novel DNA-binding proteins and for exploring fundamental principles of protein-DNA recognition.

PubMed: 9562555
DOI: 10.1016/S0969-2126(98)00047-1

Experimental method

X-RAY DIFFRACTION (1.9 Å)