1A1H

QGSR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE)

1A1H の概要

• エントリーDOI: 10.2210/pdb1a1h/pdb
• 分子名称: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*CP*CP*AP*CP*GP*C)-3'), QGSR ZINC FINGER PEPTIDE, ... (5 entities in total)
• 機能のキーワード: complex (zinc finger-dna), zinc finger, dna-binding protein, transcription-dna complex, transcription/dna
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 17629.97

構造登録者

Elrod-Erickson, M.,Benson, T.E.,Pabo, C.O. (登録日: 1997-12-10, 公開日: 1998-06-10, 最終更新日: 2024-02-07)

主引用文献

Elrod-Erickson, M.,Benson, T.E.,Pabo, C.O.
High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.
Structure, 6:451-464, 1998

PubMed Abstract: Zinc fingers of the Cys2-His2 class comprise one of the largest families of eukaryotic DNA-binding motifs and recognize a diverse set of DNA sequences. These proteins have a relatively simple modular structure and key base contacts are typically made by a few residues from each finger. These features make the zinc finger motif an attractive system for designing novel DNA-binding proteins and for exploring fundamental principles of protein-DNA recognition.

PubMed: 9562555
DOI: 10.1016/S0969-2126(98)00047-1

実験手法

X-RAY DIFFRACTION (1.6 Å)