1A1D

YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY

1A1D の概要

• エントリーDOI: 10.2210/pdb1a1d/pdb
• 分子名称: RNA POLYMERASE (1 entity in total)
• 機能のキーワード: rpb8, rna polymerase, ob fold, eukaryotic, yeast, nucleotidyltransferase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Nucleus: P20436
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16525.36

構造登録者

Krapp, S.,Kelly, G.,Reischl, J.,Weinzierl, R.,Matthews, S. (登録日: 1997-12-10, 公開日: 1999-03-02, 最終更新日: 2024-04-10)

主引用文献

Krapp, S.,Kelly, G.,Reischl, J.,Weinzierl, R.O.,Matthews, S.
Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family.
Nat.Struct.Biol., 5:110-114, 1998

PubMed Abstract: RNA polymerase II subunit RPB8 is an essential subunit that is highly conserved throughout eukaryotic evolution and is present in all three types of nuclear RNA polymerases. We report the first high resolution structural insight into eukaryotic RNA polymerase architecture with the solution structure of RPB8 from Saccharomyces cerevisiae. It consists of an eight stranded, antiparallel beta-barrel, four short helical regions and a large, unstructured omega-loop. The strands are connected in classic Greek-key fashion. The overall topology is unusual and contains a striking C2 rotational symmetry. Furthermore, it is most likely a novel associate of the oligonucleotide/oligosaccharide (OB) binding protein class.

PubMed: 9461075
DOI: 10.1038/nsb0298-110

実験手法

SOLUTION NMR