1YIN

Human estrogen receptor alpha ligand-binding domain in complex with compound 3F

Summary for 1YIN

• Entry DOI: 10.2210/pdb1yin/pdb
• Related: 1YIM
• Descriptor: Estrogen receptor, (2R,3R,4S)-5-FLUORO-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL (3 entities in total)
• Functional Keywords: nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• Total number of polymer chains: 1
• Total formula weight: 28793.89

Authors

Fitzgerald, P.M.,Sharma, N. (deposition date: 2005-01-12, release date: 2005-07-26, Last modification date: 2024-02-14)

• Primary citation: Tan, Q.,Blizzard, T.A.,Morgan, J.D.,Birzin, E.T.,Chan, W.,Yang, Y.T.,Pai, L.Y.,Hayes, E.C.,DaSilva, C.A.,Warrier, S.,Yudkovitz, J.,Wilkinson, H.A.,Sharma, N.,Fitzgerald, P.M.,Li, S.,Colwell, L.,Fisher, J.E.,Adamski, S.,Reszka, A.A.,Kimmel, D.,DiNinno, F.,Rohrer, S.P.,Freedman, L.P.,Schaeffer, J.M.,Hammond, M.L.; Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.; Bioorg.Med.Chem.Lett., 15:1675-1681, 2005; PubMed: 15745820; DOI: 10.1016/j.bmcl.2005.01.046

Experimental method

X-RAY DIFFRACTION (2.2 Å)