1N1L
CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)
1N1L の概要
エントリーDOI | 10.2210/pdb1n1l/pdb |
分子名称 | HCV NS3 SERINE PROTEASE, NS4A COFACTOR, ZINC ION, ... (5 entities in total) |
機能のキーワード | viral protein, serine protease, nonstructural proteins, cofactor peptide, helicase, inhibitor |
由来する生物種 | Hepatitis C virus 詳細 |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 47442.41 |
構造登録者 | Andrews, D.M.,Chaignot, H.,Coomber, B.A.,Good, A.C.,Hind, S.L.,Jones, P.S.,Mill, G.,Robinson, J.E.,Skarzynski, T.,Slater, M.J.,Somers, D.O.N. (登録日: 2002-10-18, 公開日: 2003-10-21, 最終更新日: 2021-10-27) |
主引用文献 | Andrews, D.M.,Chaignot, H.,Coomber, B.A.,Good, A.C.,Hind, S.L.,Johnson, M.R.,Jones, P.S.,Mill, G.,Robinson, J.E.,Skarzynski, T.,Slater, M.J.,Somers, D.O.N. Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray Crystal Structure Data in the Optimisation of P3 and P4 Substituents Org.Lett., 4:4479-4482, 2002 Cited by PubMed: 12465917DOI: 10.1021/ol027014p 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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