1JCO
Solution structure of the monomeric [Thr(B27)->Pro,Pro(B28)->Thr] insulin mutant (PT insulin)
Summary for 1JCO
Entry DOI | 10.2210/pdb1jco/pdb |
NMR Information | BMRB: 4997 |
Descriptor | Insulin A chain, Insulin B chain (2 entities in total) |
Functional Keywords | helix-turn-helix, coil-helix-coil, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01308 P01308 |
Total number of polymer chains | 2 |
Total formula weight | 5817.65 |
Authors | Keller, D.,Clausen, R.,Josefsen, K.,Led, J.J. (deposition date: 2001-06-11, release date: 2001-10-03, Last modification date: 2021-10-27) |
Primary citation | Keller, D.,Clausen, R.,Josefsen, K.,Led, J.J. Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity. Biochemistry, 40:10732-10740, 2001 Cited by PubMed: 11524020DOI: 10.1021/bi0108150 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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