1GFW
THE 2.8 ANGSTROM CRYSTAL STRUCTURE OF CASPASE-3 (APOPAIN OR CPP32)IN COMPLEX WITH AN ISATIN SULFONAMIDE INHIBITOR.
Replaces: 1QA8Summary for 1GFW
Entry DOI | 10.2210/pdb1gfw/pdb |
Related | 1cp3 1pau |
Descriptor | CASPASE-3 (APOPAIN, P20), CASPASE-3 (APOPAIN, P10), 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE, ... (4 entities in total) |
Functional Keywords | caspase inhibitor, caspase-3, apopain, istin sulfonamide, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 28463.49 |
Authors | Concha, N.O.,Janson, C.A. (deposition date: 2000-06-16, release date: 2000-06-23, Last modification date: 2023-12-27) |
Primary citation | Lee, D.,Long, S.A.,Adams, J.L.,Chan, G.,Vaidya, K.S.,Francis, T.A.,Kikly, K.,Winkler, J.D.,Sung, C.M.,Debouck, C.,Richardson, S.,Levy, M.A.,DeWolf Jr., W.E.,Keller, P.M.,Tomaszek, T.,Head, M.S.,Ryan, M.D.,Haltiwanger, R.C.,Liang, P.H.,Janson, C.A.,McDevitt, P.J.,Johanson, K.,Concha, N.O.,Chan, W.,Abdel-Meguid, S.S.,Badger, A.M.,Lark, M.W.,Nadeau, D.P.,Suva, L.J.,Gowen, M.,Nuttall, M.E. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J.Biol.Chem., 275:16007-16014, 2000 Cited by PubMed: 10821855DOI: 10.1074/jbc.275.21.16007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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