159D
SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX
Summary for 159D
| Entry DOI | 10.2210/pdb159d/pdb |
| Descriptor | DNA (5'-D(*IP*CP*IP*CP*IP*CP*IP*C)-3'), DISTAMYCIN A, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | b-dna, double helix, complexed with drug, modified, dna |
| Total number of polymer chains | 1 |
| Total formula weight | 2874.35 |
| Authors | Chen, X.,Ramakrishnan, B.,Rao, S.T.,Sundaralingam, M. (deposition date: 1994-02-10, release date: 1995-02-07, Last modification date: 2024-02-07) |
| Primary citation | Chen, X.,Ramakrishnan, B.,Rao, S.T.,Sundaralingam, M. Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex. Nat.Struct.Biol., 1:169-175, 1994 Cited by PubMed Abstract: Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides of each drug molecule are hydrogen bonded to the minor groove base atoms of only one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a dinucleotide repeat. PubMed: 7656035DOI: 10.1038/nsb0394-169 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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