157D

CRYSTAL AND MOLECULAR STRUCTURE OF R(CGCGAAUUAGCG): AN RNA DUPLEX CONTAINING TWO G(ANTI).A(ANTI) BASE-PAIRS

Summary for 157D

• Entry DOI: 10.2210/pdb157d/pdb
• Descriptor: RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') (2 entities in total)
• Functional Keywords: a-rna, double helix, mismatched, rna
• Total number of polymer chains: 2
• Total formula weight: 7702.72

Authors

Leonard, G.A.,McAuley-Hecht, K.E.,Ebel, S.,Lough, D.M.,Brown, T.,Hunter, W.N. (deposition date: 1994-02-01, release date: 1994-05-31, Last modification date: 2024-02-07)

Primary citation

Leonard, G.A.,McAuley-Hecht, K.E.,Ebel, S.,Lough, D.M.,Brown, T.,Hunter, W.N.
Crystal and molecular structure of r(CGCGAAUUAGCG): an RNA duplex containing two G(anti).A(anti) base pairs.
Structure, 2:483-494, 1994

PubMed Abstract: Non-Watson-Crick base pair associations contribute significantly to the stabilization of RNA tertiary structure. The conformation adopted by such pairs appears to be a function of both the sequence and the secondary structure of the RNA molecule. G.A mispairs adopt G(anti).A(anti) configurations in some circumstances, such as the ends of helical regions of rRNAs, but in other circumstances probably adopt an unusual configuration in which the inter-base hydrogen bonds involve functional groups from other bases. We investigated the structure of G.A pairs in a synthetic RNA dodecamer, r(CGCGAAUUAGCG), which forms a duplex containing two such mismatches.

PubMed: 7922026
DOI: 10.1016/S0969-2126(00)00049-6

Experimental method

X-RAY DIFFRACTION (1.8 Å)