157D

CRYSTAL AND MOLECULAR STRUCTURE OF R(CGCGAAUUAGCG): AN RNA DUPLEX CONTAINING TWO G(ANTI).A(ANTI) BASE-PAIRS

157D の概要

• エントリーDOI: 10.2210/pdb157d/pdb
• 分子名称: RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') (2 entities in total)
• 機能のキーワード: a-rna, double helix, mismatched, rna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7702.72

構造登録者

Leonard, G.A.,McAuley-Hecht, K.E.,Ebel, S.,Lough, D.M.,Brown, T.,Hunter, W.N. (登録日: 1994-02-01, 公開日: 1994-05-31, 最終更新日: 2024-02-07)

主引用文献

Leonard, G.A.,McAuley-Hecht, K.E.,Ebel, S.,Lough, D.M.,Brown, T.,Hunter, W.N.
Crystal and molecular structure of r(CGCGAAUUAGCG): an RNA duplex containing two G(anti).A(anti) base pairs.
Structure, 2:483-494, 1994

PubMed Abstract: Non-Watson-Crick base pair associations contribute significantly to the stabilization of RNA tertiary structure. The conformation adopted by such pairs appears to be a function of both the sequence and the secondary structure of the RNA molecule. G.A mispairs adopt G(anti).A(anti) configurations in some circumstances, such as the ends of helical regions of rRNAs, but in other circumstances probably adopt an unusual configuration in which the inter-base hydrogen bonds involve functional groups from other bases. We investigated the structure of G.A pairs in a synthetic RNA dodecamer, r(CGCGAAUUAGCG), which forms a duplex containing two such mismatches.

PubMed: 7922026
DOI: 10.1016/S0969-2126(00)00049-6

実験手法

X-RAY DIFFRACTION (1.8 Å)