103D

THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS

103D の概要

• エントリーDOI: 10.2210/pdb103d/pdb
• 分子名称: DNA (5'-D(*GP*TP*GP*GP*AP*AP*TP*GP*GP*AP*AP*C)-3') (1 entity in total)
• 機能のキーワード: dna, double helix, g-g stacking, g:a mismatch, human centromere repeat, ga-bracketed g-stack motif
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7502.93

構造登録者

Chou, S.-H.,Zhu, L.,Reid, B.R. (登録日: 1994-12-16, 公開日: 1995-03-31, 最終更新日: 2024-05-22)

主引用文献

Chou, S.H.,Zhu, L.,Reid, B.R.
The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs.
J.Mol.Biol., 244:259-268, 1994

PubMed Abstract: The centromere of human chromosomes contains multiple repeats of the DNA sequence d(TGGAA)n. This sequence has the interesting property of pairing with itself to form stable duplexes. We have determined the solution structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to form an interesting new structural motif, the GA-bracketed G-stack. The TGGAA repeat unit contains six "steps", four of which are not Watson-Crick base-pairs.

PubMed: 7966337
DOI: 10.1006/jmbi.1994.1727

実験手法

SOLUTION NMR