6OS9

human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state)

エンティティ

Entity ID	鎖名	説明	種類	鎖長	化学式量	分子数	データベース名(アクセス番号)	由来する生物種	エンティティの一般名
1	R	Neurotensin receptor type 1	polymer	435	48396.7	1	UniProt (P30989) Pfam (PF00001) In PDB	Homo sapiens (Human)	NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH
2	L	JMV449	polymer	6	763.0	1		synthetic construct
3	A	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40415.0	1	UniProt (P63096) Pfam (PF00503) In PDB	Homo sapiens (Human)	Adenylate cyclase-inhibiting G alpha protein
4	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	344	37671.1	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (Human)	Transducin beta chain 1
5	C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (Human)	G gamma-I
6	D	scFv16	polymer	259	27784.9	1		Mus musculus (mouse)

配列変更

R: 20 - 418 (UniProt: P30989)

PDB	外部データベース	詳細
Asp -19	-	expression tag
Tyr -18	-	expression tag
Lys -17	-	expression tag
Asp -16	-	expression tag
Asp -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Ala -12	-	expression tag
Met -11	-	expression tag
Gly -10	-	expression tag
Gln -9	-	expression tag
Pro -8	-	expression tag
Gly -7	-	expression tag
Asn -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
Ala -3	-	expression tag
Phe -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Ala 1	-	expression tag
Pro 2	-	expression tag
Asn 3	-	expression tag
Arg 4	-	expression tag
Ser 5	-	expression tag
His 6	-	expression tag
Ala 7	-	expression tag
Pro 8	-	expression tag
Asp 9	-	expression tag
His 10	-	expression tag
Asp 11	-	expression tag
Val 12	-	expression tag
Glu 13	-	expression tag
Asn 14	-	expression tag
Leu 15	-	expression tag
Tyr 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag
Leu 85	Ala 85	engineered mutation
-	Glu 282	deletion
-	His 283	deletion
-	Ser 284	deletion
-	Thr 285	deletion
-	Phe 286	deletion
-	Ser 287	deletion
-	Met 288	deletion
-	Ala 289	deletion
-	Ile 290	deletion
-	Glu 291	deletion
Leu 419	-	expression tag
Glu 420	-	expression tag
Val 421	-	expression tag
Leu 422	-	expression tag
Phe 423	-	expression tag
Gln 424	-	expression tag
Gly 425	-	expression tag

B: 2 - 340 (UniProt: P62873)

PDB	外部データベース	詳細
Pro -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

非対称単位の内容

タンパク質・ 核酸鎖	鎖の数	6
	化学式量合計	162891.9
全て*	化学式量合計	162891.9

*水分子は含んでいません