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6O0M

crystal structure of BCL-2 F104L mutation with venetoclax

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AApoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2polymer16619323.51UniProt (P10415)
UniProt (Q07817)
Pfam (PF02180)
Pfam (PF00452)
In PDB
Homo sapiens (Human)Bcl2-L-1,Apoptosis regulator Bcl-X
2A4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamidenon-polymer868.41Chemie (LBM)
3ADI(HYDROXYETHYL)ETHERnon-polymer106.14Chemie (PEG)
4waterwater18.086Chemie (HOH)
Sequence modifications
A: 1 - 34 (UniProt: P10415)
A: 76 - 91 (UniProt: Q07817)
A: 92 - 207 (UniProt: P10415)
PDBExternal DatabaseDetails
Leu 104Phe 104engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight19323.5
Non-Polymers*Number of molecules5
Total formula weight1292.9
All*Total formula weight20616.5
*Water molecules are not included.

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数据于2024-09-18公开中

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