6O0K

crystal structure of BCL-2 with venetoclax

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Apoptosis regulator Bcl-2	polymer	166	19357.6	1	UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	A	4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide	non-polymer		868.4	1	Chemie (LBM)
3	A	NONAETHYLENE GLYCOL	non-polymer		414.5	1	Chemie (2PE)
4		water	water		18.0	98	Chemie (HOH)

Sequence modifications

A: 1 - 34 (UniProt: P10415)
A: 35 - 91 (UniProt: Q07817)
A: 92 - 207 (UniProt: P10415)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19357.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1282.9
All*	Total formula weight	20640.5

*Water molecules are not included.