6J20
Crystal structure of the human NK1 substance P receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Substance-P receptor,Endolysin | polymer | 441 | 50484.8 | 1 | UniProt (P25103) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720) In PDB | Homo sapiens (Human) | SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1,Lysis protein,Lysozyme,Muramidase |
2 | A | 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one | non-polymer | 534.4 | 1 | Chemie (GBQ) |
Sequence modifications
A: 2 - 226 (UniProt: P25103)
A: 1001 - 1010 (UniProt: D9IEF7)
A: 1017 - 1117 (UniProt: D9IEF7)
A: 237 - 335 (UniProt: P25103)
PDB | External Database | Details |
---|---|---|
Asn 78 | Glu 78 | engineered mutation |
Trp 121 | Tyr 121 | engineered mutation |
Arg 222 | Thr 222 | engineered mutation |
A: 1017 - 1117 (UniProt: D9IEF7)
PDB | External Database | Details |
---|---|---|
Gly 1011 | - | linker |
Gly 1012 | - | linker |
Gly 1013 | - | linker |
Ser 1014 | - | linker |
Gly 1015 | - | linker |
Gly 1016 | - | linker |
Ala 1053 | Cys 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 50484.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 534.4 | |
All* | Total formula weight | 51019.3 |