6C9J

AMP-activated protein kinase bound to pharmacological activator R734

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	5'-AMP-activated protein kinase catalytic subunit alpha-1	polymer	494	57245.6	1	UniProt (Q13131) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB	Homo sapiens (Human)	AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1
2	B	5'-AMP-activated protein kinase subunit beta-1	polymer	204	23071.3	1	UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) In PDB	Homo sapiens (Human)	AMPKb
3	C	5'-AMP-activated protein kinase subunit gamma-1	polymer	325	37027.6	1	UniProt (P54619) Pfam (PF00571) In PDB	Homo sapiens (Human)	AMPKg
4	A	5-{[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy}-N-hydroxy-2-methylbenzamide	non-polymer		446.9	1	Chemie (R34)
5	A	STAUROSPORINE	non-polymer		466.5	1	Chemie (STU)
6	C	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	1	Chemie (AMP)

Sequence modifications

A: 13 - 471 (UniProt: Q13131)

PDB	External Database	Details
Met 3	-	expression tag
Gly 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag

A: 526 - 550 (UniProt: Q13131)
B: 68 - 270 (UniProt: Q9Y478)

PDB	External Database	Details
Met 67	-	expression tag
Asp 108	Ser 108	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	117344.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1260.6
All*	Total formula weight	118605.2

*Water molecules are not included.