5T5T
AMPK bound to allosteric activator
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 503 | 57779.1 | 1 | UniProt (P54645) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | Rattus norvegicus (Rat) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
2 | B | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 204 | 23055.3 | 1 | UniProt (P80386) Pfam (PF16561) Pfam (PF04739) In PDB | Rattus norvegicus (Rat) | AMPKb,5'-AMP-activated protein kinase 40 kDa subunit |
3 | C | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) In PDB | Rattus norvegicus (Rat) | AMPKg |
4 | A | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
6 | A, C | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | B | 6-chloro-5-[6-(dimethylamino)-2-methoxypyridin-3-yl]-1H-indole-3-carboxylic acid | non-polymer | 345.8 | 1 | Chemie (75O) | |||
8 | C | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
9 | C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
A: 0 - 548 (UniProt: P54645)
B: 68 - 270 (UniProt: P80386)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
- | Ile 481 | deletion |
- | Thr 482 | deletion |
- | Glu 483 | deletion |
- | Ala 484 | deletion |
- | Lys 485 | deletion |
- | Ser 486 | deletion |
- | Gly 487 | deletion |
- | Thr 488 | deletion |
- | Ala 489 | deletion |
- | Thr 490 | deletion |
- | Pro 491 | deletion |
- | Gln 492 | deletion |
- | Arg 493 | deletion |
- | Ser 494 | deletion |
- | Gly 495 | deletion |
- | Ser 496 | deletion |
- | Ile 497 | deletion |
- | Ser 498 | deletion |
- | Asn 499 | deletion |
- | Tyr 500 | deletion |
- | Arg 501 | deletion |
- | Ser 502 | deletion |
- | Cys 503 | deletion |
- | Gln 504 | deletion |
- | Arg 505 | deletion |
- | Ser 506 | deletion |
- | Asp 507 | deletion |
- | Ser 508 | deletion |
- | Asp 509 | deletion |
- | Ala 510 | deletion |
- | Glu 511 | deletion |
- | Ala 512 | deletion |
- | Gln 513 | deletion |
- | Gly 514 | deletion |
- | Lys 515 | deletion |
- | Pro 516 | deletion |
- | Ser 517 | deletion |
- | Glu 518 | deletion |
- | Val 519 | deletion |
- | Ser 520 | deletion |
- | Leu 521 | deletion |
- | Thr 522 | deletion |
- | Ser 523 | deletion |
- | Ser 524 | deletion |
- | Val 525 | deletion |
- | Thr 526 | deletion |
- | Ser 527 | deletion |
Ala 517 | Leu 528 | linker |
Ser 518 | Asp 529 | linker |
Gly 519 | Ser 530 | linker |
Gly 520 | Ser 531 | linker |
Gly 522 | Val 533 | linker |
Gly 523 | Asp 534 | linker |
Ser 524 | Val 535 | linker |
PDB | External Database | Details |
---|---|---|
Met 67 | - | initiating methionine |
Asp 108 | Ser 108 | engineered mutation |
His 109 | Gln 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 118268.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 2232.4 | |
All* | Total formula weight | 120501.0 |