5KQ5
AMPK bound to allosteric activator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 503 | 57779.1 | 1 | UniProt (P54645) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | Rattus norvegicus (Rat) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
| 2 | B | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 204 | 23045.3 | 1 | UniProt (P80386) Pfam (PF16561) Pfam (PF04739) In PDB | Rattus norvegicus (Rat) | AMPKb,5'-AMP-activated protein kinase 40 kDa subunit |
| 3 | C | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) In PDB | Rattus norvegicus (Rat) | AMPKg |
| 4 | A | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
| 5 | A | 6-chloranyl-5-[4-(1-oxidanylcyclobutyl)phenyl]-1~{H}-indole-3-carboxylic acid | non-polymer | 341.8 | 1 | Chemie (6VT) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 7 | C | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 8 | C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 9 | C | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A: 0 - 548 (UniProt: P54645)
B: 68 - 270 (UniProt: P80386)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| - | Ile 481 | deletion |
| - | Thr 482 | deletion |
| - | Glu 483 | deletion |
| - | Ala 484 | deletion |
| - | Lys 485 | deletion |
| - | Ser 486 | deletion |
| - | Gly 487 | deletion |
| - | Thr 488 | deletion |
| - | Ala 489 | deletion |
| - | Thr 490 | deletion |
| - | Pro 491 | deletion |
| - | Gln 492 | deletion |
| - | Arg 493 | deletion |
| - | Ser 494 | deletion |
| - | Gly 495 | deletion |
| - | Ser 496 | deletion |
| - | Ile 497 | deletion |
| - | Ser 498 | deletion |
| - | Asn 499 | deletion |
| - | Tyr 500 | deletion |
| - | Arg 501 | deletion |
| - | Ser 502 | deletion |
| - | Cys 503 | deletion |
| - | Gln 504 | deletion |
| - | Arg 505 | deletion |
| - | Ser 506 | deletion |
| - | Asp 507 | deletion |
| - | Ser 508 | deletion |
| - | Asp 509 | deletion |
| - | Ala 510 | deletion |
| - | Glu 511 | deletion |
| - | Ala 512 | deletion |
| - | Gln 513 | deletion |
| - | Gly 514 | deletion |
| - | Lys 515 | deletion |
| - | Pro 516 | deletion |
| - | Ser 517 | deletion |
| - | Glu 518 | deletion |
| - | Val 519 | deletion |
| - | Ser 520 | deletion |
| - | Leu 521 | deletion |
| - | Thr 522 | deletion |
| - | Ser 523 | deletion |
| - | Ser 524 | deletion |
| - | Val 525 | deletion |
| - | Thr 526 | deletion |
| - | Ser 527 | deletion |
| Ala 517 | Leu 528 | linker |
| Ser 518 | Asp 529 | linker |
| Gly 519 | Ser 530 | linker |
| Gly 520 | Ser 531 | linker |
| Gly 522 | Val 533 | linker |
| Gly 523 | Asp 534 | linker |
| Ser 524 | Val 535 | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| Asp 108 | Ser 108 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118258.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2167.8 | |
| All* | Total formula weight | 120426.3 |
