5IZQ
Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Folate receptor alpha | polymer | 238 | 27715.5 | 8 | UniProt (P15328) Pfam (PF03024) In PDB | Homo sapiens (Human) | FR-alpha,Adult folate-binding protein,FBP,Folate receptor 1,Folate receptor,adult,KB cells FBP,Ovarian tumor-associated antigen MOv18 |
| 2 | A, B, C, E, F... | N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid | non-polymer | 442.4 | 7 | Chemie (83A) |
Sequence modifications
A, B, C, D, E, F, G, H: -21 - 213 (UniProt: P15328)
| PDB | External Database | Details |
|---|---|---|
| Thr 214 | - | expression tag |
| Leu 215 | - | expression tag |
| Val 216 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 221724.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3097.0 | |
| All* | Total formula weight | 224821.2 |
