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5HG7

EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AEpidermal growth factor receptorpolymer32937580.51UniProt (P00533)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2A1-{(3R,4R)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}propan-1-onenon-polymer433.91Chemie (630)
3ASULFATE IONnon-polymer96.11Chemie (SO4)
4waterwater18.0219Chemie (HOH)
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
Gly 694-expression tag
Met 790Thr 790engineered mutation
Arg 858Leu 858engineered mutation
Arg 948Val 948engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight37580.5
Non-Polymers*Number of molecules2
Total formula weight530.0
All*Total formula weight38110.4
*Water molecules are not included.

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數據於2024-09-18公開中

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