4PPC
ITK kinase domain with compound 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1-PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase ITK/TSK | polymer | 266 | 30214.5 | 2 | UniProt (Q08881) Pfam (PF07714) In PDB | Homo sapiens (human) | Interleukin-2-inducible T-cell kinase, IL-2-inducible T-cell kinase, Kinase EMT, T-cell-specific kinase, Tyrosine-protein kinase Lyk |
2 | A, B | N-{1-[(1R)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide | non-polymer | 454.5 | 2 | Chemie (2VW) |
Sequence modifications
A, B: 357 - 620 (UniProt: Q08881)
PDB | External Database | Details |
---|---|---|
Gly 355 | - | expression tag |
Ser 356 | - | expression tag |
Glu 512 | Tyr 512 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 60429.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 909.1 | |
All* | Total formula weight | 61338.0 |