2YHV

Structure of L1196M Mutant Anaplastic Lymphoma Kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ALK TYROSINE KINASE RECEPTOR	polymer	342	38614.2	1	UniProt (Q9UM73) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	ANAPLASTIC LYMPHOMA KINASE, CD_ANTIGEN=CD246
2		water	water		18.0	197	Chemie (HOH)

Sequence modifications

A: 1093 - 1411 (UniProt: Q9UM73)

PDB	External Database	Details
Met 1070	-	expression tag
Ala 1071	-	expression tag
His 1072	-	expression tag
His 1073	-	expression tag
His 1074	-	expression tag
His 1075	-	expression tag
His 1076	-	expression tag
His 1077	-	expression tag
Asp 1078	-	expression tag
Tyr 1079	-	expression tag
Gly 1080	-	expression tag
Ile 1081	-	expression tag
Pro 1082	-	expression tag
Thr 1083	-	expression tag
Thr 1084	-	expression tag
Glu 1085	-	expression tag
Asn 1086	-	expression tag
Leu 1087	-	expression tag
Tyr 1088	-	expression tag
Phe 1089	-	expression tag
Gln 1090	-	expression tag
Gly 1091	-	expression tag
Ser 1092	-	expression tag
Met 1196	Leu 1196	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38614.2
All*	Total formula weight	38614.2

*Water molecules are not included.