1OI9
Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | CELL DIVISION PROTEIN KINASE 2 | polymer | 302 | 34354.8 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | P33 PROTEIN KINASE, CDK2 |
2 | B, D | CYCLIN A2 | polymer | 260 | 29884.6 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | HOMO SAPIENS (HUMAN) | CYCLIN A, CCNA2, CCNA, CCN1 |
3 | A, C | 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE | non-polymer | 339.4 | 2 | Chemie (N20) | |||
4 | B, D | MONOTHIOGLYCEROL | non-polymer | 108.2 | 2 | Chemie (SGM) | |||
5 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | water | water | 18.0 | 341 | Chemie (HOH) |
Sequence modifications
A, C: -3 - 0 (PDB: 1OI9)
A, C: 1 - 298 (UniProt: P24941)
B, D: 173 - 173 (PDB: 1OI9)
B, D: 174 - 432 (UniProt: P20248)
A, C: 1 - 298 (UniProt: P24941)
B, D: 173 - 173 (PDB: 1OI9)
B, D: 174 - 432 (UniProt: P20248)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 128478.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 919.4 | |
All* | Total formula weight | 129398.2 |