1LPQ

Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'	polymer	22	6822.5	1
2	C	5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'	polymer	22	6690.4	1
3	A	DNA topoisomerase I	polymer	564	66767.1	1	UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB	Homo sapiens (human)
4		water	water		18.0	27	Chemie (HOH)

Sequence modifications

A: 202 - 765 (UniProt: P11387)

PDB	External Database	Details
Phe 723	Tyr 723	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	80279.9
All*	Total formula weight	80279.9

*Water molecules are not included.