Mine: New entries

6CRH
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH 8-CLG IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE GTP
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(CGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.-C., Lee, S.
Deposit date:2018-03-17
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.327 Å)
Cite:Structure of human DNA polymerase beta complexed with 8-ClG in the template base paired with incoming non-hydrolyzable CTP
To Be Published
6CZN
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ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN Y537S MUTANT IN COMPLEX WITH Z2OHTPE AND A GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1 NR BOX II PEPTIDE
Descriptor:Estrogen receptor, GRIP Peptide, 4,4'-[(1R,2R)-1-phenylbutane-1,2-diyl]diphenol
Authors:Fanning, S.W., Han, R., Maximov, P., Jordan, V.C., Greene, G.L.
Deposit date:2018-04-09
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Z2OHTPE and a glucocorticoid receptor-interacting protein 1 NR box II peptide
To Be Published
6D2I
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JAK2 PSEUDOKINASE V617F IN COMPLEX WITH AT9283
Descriptor:Tyrosine-protein kinase, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea
Authors:Li, Q., Li, K., Eck, M.J.
Deposit date:2018-04-13
Release date:2019-03-20
Method:X-RAY DIFFRACTION (3.192 Å)
Cite:Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain.
ACS Chem. Biol., 2019
6DC7
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APO FAB STRUCTURE OF MOUSE MONOCLONAL ANTIBODY 8B2
Descriptor:Fab light chain, Fab heavy chain
Authors:Chukwu, J.E., Kong, X.-P.
Deposit date:2018-05-04
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.
MAbs, 2019
6DC8
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FAB/EPITOPE COMPLEX OF MOUSE MONOCLONAL ANTIBODY 8B2 TARGETING A NON-PHOSPHORYLATED TAU EPITOPE.
Descriptor:IgG light chain, IgG heavy chain, Microtubule-associated protein tau, ...
Authors:Chukwu, J.E., Kong, X.-P.
Deposit date:2018-05-04
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.
MAbs, 2019
6DC9
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FAB/EPITOPE COMPLEX OF HUMAN CHIMERIC MONOCLONAL ANTIBODY H4E6 TARGETING A PHOSPHORYLATED TAU EPITOPE.
Descriptor:Fab heavy chain, Fab light chain, Microtubule-associated protein tau, ...
Authors:Chukwu, J.E., Kong, X.-P.
Deposit date:2018-05-04
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.
MAbs, 2019
6DCA
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FAB/EPITOPE COMPLEX OF MOUSE MONOCLONAL ANTIBODY 6B2 TARGETING A NON-PHOSPHORYLATED TAU EPITOPE.
Descriptor:Fab light chain, Fab heavy chain, Microtubule-associated protein tau, ...
Authors:Chukwu, J.E., Kong, X.-P.
Deposit date:2018-05-04
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.
MAbs, 2019
6DCD
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MYCOBACTERIUM MARINUM CYTOCHROME P450 CYP150A6 IN THE SUBSTRATE-FREE FORM
Descriptor:Cytochrome P450 150A6 Cyp150A6, PROTOPORPHYRIN IX CONTAINING FE
Authors:Child, S.A., Bruning, J.B., Bell, S.G.
Deposit date:2018-05-05
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The characterisation of two members of the cytochrome P450 CYP150 family: CYP150A5 and CYP150A6 from Mycobacterium marinum.
Biochim Biophys Acta Gen Subj, 2019
6DDA
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NURR1 COVALENTLY MODIFIED BY A DOPAMINE METABOLITE
Descriptor:Nuclear receptor subfamily 4 group A member 2, POTASSIUM ION, 5-hydroxy-1,2-dihydro-6H-indol-6-one, ...
Authors:Bruning, J.M., Wang, Y., Otrabella, F., Boxue, T., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M.
Deposit date:2018-05-09
Release date:2019-03-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Nurr1 Covalently Modified by a Dopamine Metabolite
To Be Published
6DDD
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STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN COMPLEX WITH THE OXAZOLIDINONE ANTIBIOTIC LZD-5
Descriptor:50S ribosomal protein L19, 50S ribosomal protein L2, 50S ribosomal protein L20, ...
Authors:Belousoff, M.J., Venugopal, H., Bamert, R.S., Lithgow, T.
Deposit date:2018-05-10
Release date:2019-03-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria.
ChemMedChem, 14, 2019
6DDG
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STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN COMPLEX WITH THE OXAZOLIDINONE ANTIBIOTIC LZD-6
Descriptor:50S ribosomal protein L19, 50S ribosomal protein L2, 50S ribosomal protein L20, ...
Authors:Belousoff, M.J., Venugopal, H., Bamert, R.S., Lithgow, T.
Deposit date:2018-05-10
Release date:2019-03-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria.
ChemMedChem, 14, 2019
6DET
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THE CRYSTAL STRUCTURE OF TV2483 BOUND TO L-ARGININE
Descriptor:Tv2483, ARGININE
Authors:Brautigam, C.A., Norgard, M.V.
Deposit date:2018-05-13
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biophysical insights into a highly selective l-arginine-binding lipoprotein of a pathogenic treponeme.
Protein Sci., 27, 2018
6DK7
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RETS HISTIDINE KINASE REGION WITH COBALT
Descriptor:RetS (Regulator of Exopolysaccharide and Type III Secretion), COBALT (II) ION
Authors:Mancl, J.M., Schubot, F.D.
Deposit date:2018-05-29
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa
Structure, 2019
6DK8
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RETS KINASE REGION WITHOUT COBALT
Descriptor:RetS (Regulator of Exopolysaccharide and Type III Secretion), NICKEL (II) ION
Authors:Mancl, J.M., Schubot, F.D.
Deposit date:2018-05-29
Release date:2019-03-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa
Structure, 2019
6DYU
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI 5'-METHYLTHIOADENOSINE/S-ADENOSYL HOMOCYSTEINE NUCLEOSIDASE (MTAN) COMPLEXED WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-((PROP-2-YN-1-YLTHIO)METHYL)PYRROLIDIN-3-OL
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 1,2-ETHANEDIOL, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(prop-2-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DYV
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI 5'-METHYLTHIOADENOSINE/S-ADENOSYL HOMOCYSTEINE NUCLEOSIDASE (MTAN) COMPLEXED WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-((PENT-4-YN-1-YLTHIO)METHYL)PYRROLIDIN-3-OL
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 1,2-ETHANEDIOL, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DYW
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI 5'-METHYLTHIOADENOSINE/S-ADENOSYL HOMOCYSTEINE NUCLEOSIDASE (MTAN) COMPLEXED WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-(((3-(1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)PROPYL)THIO)METHYL)PYRROLIDIN-3-OL
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 1,2-ETHANEDIOL, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DYY
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI 5'-METHYLTHIOADENOSINE/S-ADENOSYL HOMOCYSTEINE NUCLEOSIDASE (MTAN) COMPLEXED WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-(((3-(1-BUTYL-1H-1,2,3-TRIAZOL-4-YL)PROPYL)THIO)METHYL)PYRROLIDIN-3-OL
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DYZ
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CRYSTAL STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE IN COMPLEX WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-((PROP-2-YN-1-YLTHIO)METHYL)PYRROLIDIN-3-OL
Descriptor:S-methyl-5'-thioadenosine phosphorylase, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DZ0
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CRYSTAL STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE IN COMPLEX WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-((PENT-4-YN-1-YLTHIO)METHYL)PYRROLIDIN-3-OL
Descriptor:S-methyl-5'-thioadenosine phosphorylase, PHOSPHATE ION, 1,2-ETHANEDIOL, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DZ2
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CRYSTAL STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE IN COMPLEX WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-(((3-(1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)PROPYL)THIO)METHYL)PYRROLIDIN-3-OL
Descriptor:S-methyl-5'-thioadenosine phosphorylase, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6DZ3
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CRYSTAL STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE IN COMPLEX WITH (3R,4S)-1-((4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL)-4-(((3-(1-BUTYL-1H-1,2,3-TRIAZOL-4-YL)PROPYL)THIO)METHYL)PYRROLIDIN-3-OL
Descriptor:S-methyl-5'-thioadenosine phosphorylase, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Harijan, R.K., Ducati, R.G., Bonanno, J.B., Almo, S.C., Schramm, V.L.
Deposit date:2018-07-02
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:"Selective inhibitors of H. pylori methylthioadenosine nucleosidase and human methylthioadenosine phosphorylase".
J. Med. Chem., 2019
6E20
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CRYSTAL STRUCTURE OF THE DARIO RERIO GALECTIN-1-L2
Descriptor:Galectin, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, BETA-D-GALACTOSE, ...
Authors:Ghosh, A., Bianchet, M.A.
Deposit date:2018-07-10
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the zebrafish galectin-1-L2 and model of its interaction with the infectious hematopoietic necrosis virus (IHNV) envelope glycoprotein.
Glycobiology, 2019
6E3A
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TRNA 2'-PHOSPHOTRANSFERASE
Descriptor:Probable RNA 2'-phosphotransferase, COENZYME A, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate
Authors:Shuman, S., Goldgur, Y., Banerjee, A.
Deposit date:2018-07-13
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4recognition and ADP-ribosylation.
Nat Commun, 10, 2019
6EDE
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TRNA 2'-PHOSPHOTRANSFERASE
Descriptor:Probable RNA 2'-phosphotransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate
Authors:Shuman, S., Goldgur, Y., Banerjee, A.
Deposit date:2018-08-09
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4recognition and ADP-ribosylation.
Nat Commun, 10, 2019