Summary
| Title: | Crystal structure of a CDK6/Vcyclin complex with inhibitor bound |
| Citation: | Li, Z.,Wang, X.,Eksterowicz, J.,Gribble, M.W.,Alba, G.Q.,Ayres, M.,Carlson, T.J.,Chen, A.,Chen, X.,Cho, R.,Connors, R.V.,Degraffenreid, M.,Deignan, J.T.,Duquette, J.,Fan, P.,Fisher, B.,Fu, J.,Huard, J.N.,Kaizerman, J.,Keegan, K.S.,Li, C.,Li, K.,Li, Y.,Liang, L.,Liu, W.,Lively, S.E.,Lo, M.C.,Ma, J.,McMinn, D.L.,Mihalic, J.T.,Modi, K.,Ngo, R.,Pattabiraman, K.,Piper, D.E.,Queva, C.,Ragains, M.L.,Suchomel, J.,Thibault, S.,Walker, N.,Wang, X.,Wang, Z.,Wanska, M.,Wehn, P.M.,Weidner, M.F.,Zhang, A.J.,Zhao, X.,Kamb, A.,Wickramasinghe, D.,Dai, K.,McGee, L.R.,Medina, J.C. Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3. J.Med.Chem., 2014 PubMed: 24641103DOI: 10.1021/jm500118j |
| Experimental method: | X-RAY DIFFRACTION (2.9 Å) |
| Deposition date: | 2014-03-10 |
| Release date: | 2014-04-30 |
| Obsoletion date: | 2014-08-06 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 4p41.cif.gz Display(109.44 KB) 4p41.cif | ||
| PDBML | all | 4p41.xml.gz Display(147.48 KB) 4p41.xml | |
| PDB | pdb4p41.ent.gz Display(87.12 KB) pdb4p41.ent | ||
| Structure factors | r4p41sf.ent.gz Display(901.57 KB) r4p41sf.ent | ||
