Summary
| Title: | Crystal structure of human beta secretase complexed with spiropiperdine imidohydantoin inhibitor. |
| Citation: | Barrow, J.C.,Stauffer, S.R.,Rittle, K.E.,Ngo, P.L.,Yang, Z.,Selnick, H.G.,Graham, S.L.,Munshi, S.,McGaughey, G.B.,Holloway, M.K.,Simon, A.J.,Price, E.A.,Sankaranarayanan, S.,Colussi, D.,Tugusheva, K.,Lai, M.T.,Espeseth, A.S.,Xu, M.,Huang, Q.,Wolfe, A.,Pietrak, B.,Zuck, P.,Levorse, D.A.,Hazuda, D.,Vacca, J.P. Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of beta-Secretase. J.Med.Chem., 51:6259-6262, 2008 PubMed: 18811140DOI: 10.1021/jm800914n |
| Experimental method: | X-RAY DIFFRACTION (1.9 Å) |
| Deposition date: | 2008-08-08 |
| Release date: | 2008-10-28 |
| Obsoletion date: | 2009-01-20 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 3e3w.cif.gz Display(91.06 KB) 3e3w.cif | ||
| PDBx/mmJSON | no-atom | 3e3w-noatom.json.gz Display (Header)(14.57 KB) 3e3w-noatom.json | |
| PDBML | all | 3e3w.xml.gz Display(122.65 KB) 3e3w.xml | |
| PDB | pdb3e3w.ent.gz Display(73.08 KB) pdb3e3w.ent | ||
| Structure factors | r3e3wsf.ent.gz Display(385.17 KB) r3e3wsf.ent | ||
