6GGE
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006915 | biological_process | apoptotic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006915 | biological_process | apoptotic process |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 4 |
| 詳細 | binding site for residue ZN A 401 |
| 鎖名 | 残基 |
| A | CYS176 |
| A | HIS179 |
| A | CYS238 |
| A | CYS242 |
| site_id | AC2 |
| 残基数 | 10 |
| 詳細 | binding site for residue EYE A 402 |
| 鎖名 | 残基 |
| A | PRO222 |
| A | PRO223 |
| A | ASP228 |
| A | THR230 |
| A | HOH582 |
| A | LEU145 |
| A | VAL147 |
| A | THR150 |
| A | CYS220 |
| A | GLU221 |
| site_id | AC3 |
| 残基数 | 4 |
| 詳細 | binding site for residue ZN B 401 |
| 鎖名 | 残基 |
| B | CYS176 |
| B | HIS179 |
| B | CYS238 |
| B | CYS242 |
| site_id | AC4 |
| 残基数 | 12 |
| 詳細 | binding site for residue EYE B 402 |
| 鎖名 | 残基 |
| B | LEU145 |
| B | VAL147 |
| B | THR150 |
| B | PRO151 |
| B | PRO152 |
| B | PRO153 |
| B | CYS220 |
| B | GLU221 |
| B | PRO222 |
| B | PRO223 |
| B | ASP228 |
| B | THR230 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 380 |
| 詳細 | DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| 鎖名 | 残基 | 詳細 |
| A | THR102-LYS292 | |
| B | THR102-LYS292 |
| site_id | SWS_FT_FI2 |
| 残基数 | 8 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 |
| 鎖名 | 残基 | 詳細 |
| A | CYS176 | |
| A | HIS179 | |
| A | CYS238 | |
| A | CYS242 | |
| B | CYS176 | |
| B | HIS179 | |
| B | CYS238 | |
| B | CYS242 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| 鎖名 | 残基 | 詳細 |
| A | LYS120 | |
| B | LYS120 |
| site_id | SWS_FT_FI4 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-acetyllysine; by KAT6A => ECO:0000269|PubMed:23431171 |
| 鎖名 | 残基 | 詳細 |
| A | LYS120 | |
| B | LYS120 |
| site_id | SWS_FT_FI5 |
| 残基数 | 4 |
| 詳細 | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
| 鎖名 | 残基 | 詳細 |
| A | SER183 | |
| A | SER269 | |
| B | SER183 | |
| B | SER269 |
| site_id | SWS_FT_FI6 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
| 鎖名 | 残基 | 詳細 |
| A | THR284 | |
| B | THR284 |
| site_id | SWS_FT_FI7 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314 |
| 鎖名 | 残基 | 詳細 |
| A | LYS305 | |
| B | LYS305 |
| site_id | SWS_FT_FI8 |
| 残基数 | 6 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
| 鎖名 | 残基 | 詳細 |
| A | LYS291 | |
| A | LYS292 | |
| B | LYS291 | |
| B | LYS292 |
