6AHR

Cryo-EM structure of human Ribonuclease P

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000172	cellular_component	ribonuclease MRP complex
B	0001682	biological_process	tRNA 5'-leader removal
B	0003723	molecular_function	RNA binding
B	0004526	molecular_function	ribonuclease P activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005655	cellular_component	nucleolar ribonuclease P complex
B	0005730	cellular_component	nucleolus
B	0008033	biological_process	tRNA processing
B	0016078	biological_process	tRNA decay
B	0030681	cellular_component	multimeric ribonuclease P complex
B	0033204	molecular_function	ribonuclease P RNA binding
C	0000172	cellular_component	ribonuclease MRP complex
C	0001650	cellular_component	fibrillar center
C	0001682	biological_process	tRNA 5'-leader removal
C	0003723	molecular_function	RNA binding
C	0004526	molecular_function	ribonuclease P activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005655	cellular_component	nucleolar ribonuclease P complex
C	0005730	cellular_component	nucleolus
C	0006364	biological_process	rRNA processing
C	0008033	biological_process	tRNA processing
C	0030681	cellular_component	multimeric ribonuclease P complex
C	0033204	molecular_function	ribonuclease P RNA binding
D	0000172	cellular_component	ribonuclease MRP complex
D	0001682	biological_process	tRNA 5'-leader removal
D	0003723	molecular_function	RNA binding
D	0004526	molecular_function	ribonuclease P activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0008033	biological_process	tRNA processing
D	0030677	cellular_component	ribonuclease P complex
D	0030681	cellular_component	multimeric ribonuclease P complex
D	0033204	molecular_function	ribonuclease P RNA binding
D	0034470	biological_process	obsolete ncRNA processing
E	0000172	cellular_component	ribonuclease MRP complex
E	0001682	biological_process	tRNA 5'-leader removal
E	0003723	molecular_function	RNA binding
E	0004526	molecular_function	ribonuclease P activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005655	cellular_component	nucleolar ribonuclease P complex
E	0005730	cellular_component	nucleolus
E	0006364	biological_process	rRNA processing
E	0008033	biological_process	tRNA processing
E	0030677	cellular_component	ribonuclease P complex
E	0030681	cellular_component	multimeric ribonuclease P complex
E	0033204	molecular_function	ribonuclease P RNA binding
E	1902555	cellular_component	endoribonuclease complex
E	1990904	cellular_component	ribonucleoprotein complex
F	0000172	cellular_component	ribonuclease MRP complex
F	0001682	biological_process	tRNA 5'-leader removal
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0004526	molecular_function	ribonuclease P activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0006364	biological_process	rRNA processing
F	0008033	biological_process	tRNA processing
F	0030681	cellular_component	multimeric ribonuclease P complex
F	0033204	molecular_function	ribonuclease P RNA binding
F	0034451	cellular_component	centriolar satellite
G	0000172	cellular_component	ribonuclease MRP complex
G	0001682	biological_process	tRNA 5'-leader removal
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0004526	molecular_function	ribonuclease P activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005655	cellular_component	nucleolar ribonuclease P complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006364	biological_process	rRNA processing
G	0006396	biological_process	RNA processing
G	0008033	biological_process	tRNA processing
G	0030681	cellular_component	multimeric ribonuclease P complex
G	0033204	molecular_function	ribonuclease P RNA binding
G	0043231	cellular_component	intracellular membrane-bounded organelle
H	0001682	biological_process	tRNA 5'-leader removal
H	0003723	molecular_function	RNA binding
H	0004526	molecular_function	ribonuclease P activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0008033	biological_process	tRNA processing
H	0030677	cellular_component	ribonuclease P complex
H	0030681	cellular_component	multimeric ribonuclease P complex
H	0033204	molecular_function	ribonuclease P RNA binding
H	1902555	cellular_component	endoribonuclease complex
H	1990904	cellular_component	ribonucleoprotein complex
I	0000172	cellular_component	ribonuclease MRP complex
I	0001682	biological_process	tRNA 5'-leader removal
I	0003723	molecular_function	RNA binding
I	0004526	molecular_function	ribonuclease P activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005655	cellular_component	nucleolar ribonuclease P complex
I	0005730	cellular_component	nucleolus
I	0006364	biological_process	rRNA processing
I	0008033	biological_process	tRNA processing
I	0030681	cellular_component	multimeric ribonuclease P complex
I	0033204	molecular_function	ribonuclease P RNA binding
J	0000172	cellular_component	ribonuclease MRP complex
J	0001682	biological_process	tRNA 5'-leader removal
J	0003723	molecular_function	RNA binding
J	0004526	molecular_function	ribonuclease P activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005655	cellular_component	nucleolar ribonuclease P complex
J	0005730	cellular_component	nucleolus
J	0006364	biological_process	rRNA processing
J	0008033	biological_process	tRNA processing
J	0030681	cellular_component	multimeric ribonuclease P complex
J	0033204	molecular_function	ribonuclease P RNA binding
K	0001682	biological_process	tRNA 5'-leader removal
K	0003723	molecular_function	RNA binding
K	0004526	molecular_function	ribonuclease P activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005655	cellular_component	nucleolar ribonuclease P complex
K	0005730	cellular_component	nucleolus
K	0006396	biological_process	RNA processing
K	0008033	biological_process	tRNA processing
K	0009410	biological_process	response to xenobiotic stimulus
K	0030681	cellular_component	multimeric ribonuclease P complex
K	0033204	molecular_function	ribonuclease P RNA binding
K	0034470	biological_process	obsolete ncRNA processing
K	0046872	molecular_function	metal ion binding
K	1902555	cellular_component	endoribonuclease complex
K	1990904	cellular_component	ribonucleoprotein complex
L	0000171	molecular_function	ribonuclease MRP activity
L	0000172	cellular_component	ribonuclease MRP complex
L	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L	0001682	biological_process	tRNA 5'-leader removal
L	0003723	molecular_function	RNA binding
L	0004526	molecular_function	ribonuclease P activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005655	cellular_component	nucleolar ribonuclease P complex
L	0005730	cellular_component	nucleolus
L	0006364	biological_process	rRNA processing
L	0008033	biological_process	tRNA processing
L	0030677	cellular_component	ribonuclease P complex
L	0030681	cellular_component	multimeric ribonuclease P complex
L	0033204	molecular_function	ribonuclease P RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN K 201

Chain	Residue
K	CYS62
K	GLY64
K	CYS65
K	CYS92
K	CYS95

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
K	CYS62
K	CYS65
K	CYS92
K	CYS95

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
K	ALA2
J	SER251

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
C	SER226

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER235

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