5ZNI

Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine

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Functional Information from GO Data

ChainGOidnamespacecontents
A0004731molecular_functionpurine-nucleoside phosphorylase activity
A0009116biological_processnucleoside metabolic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC110binding site for residue PO4 A 301
ChainResidue
AGLY23
AARG27
AARG45
AARG88
AGLY90
ASER91
AYMZ302
AHOH409
AHOH410
AHOH427

AC215binding site for residue YMZ A 302
ChainResidue
AHIS7
AARG45
ACYS92
AGLY93
ATYR160
AVAL181
AGLU182
AMET183
AASP206
AGLY207
ACYS208
APRO209
APO4301
AHOH401
AHOH442

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
YMZ_5zni_A_30217Mefloquine binding site
ChainResidueligand
AVAL66YMZ: Mefloquine
ASER91-SER94YMZ: Mefloquine
ASER157YMZ: Mefloquine
AMET159-TYR160YMZ: Mefloquine
ALEU170YMZ: Mefloquine
AVAL181-GLU184YMZ: Mefloquine
AASP206-PRO209YMZ: Mefloquine

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails